diff --git a/src/main/ipc.ts b/src/main/ipc.ts
index 72ffa81a38..b5424c81ab 100644
--- a/src/main/ipc.ts
+++ b/src/main/ipc.ts
@@ -3,7 +3,7 @@ import { arch } from 'node:os'
 import path from 'node:path'
 
 import { loggerService } from '@logger'
-import { isLinux, isMac, isWin } from '@main/constant'
+import { isLinux, isMac, isPortable, isWin } from '@main/constant'
 import { getBinaryPath, isBinaryExists, runInstallScript } from '@main/utils/process'
 import { handleZoomFactor } from '@main/utils/zoom'
 import { UpgradeChannel } from '@shared/config/constant'
@@ -335,6 +335,12 @@ export function registerIpc(mainWindow: BrowserWindow, app: Electron.App) {
       options.args.unshift('--appimage-extract-and-run')
     }
 
+    if (isWin && isPortable) {
+      options = options || {}
+      options.execPath = process.env.PORTABLE_EXECUTABLE_FILE
+      options.args = options.args || []
+    }
+
     app.relaunch(options)
     app.exit(0)
   })
diff --git a/src/main/utils/file.ts b/src/main/utils/file.ts
index 4f67fd6504..19d37b28f6 100644
--- a/src/main/utils/file.ts
+++ b/src/main/utils/file.ts
@@ -4,7 +4,7 @@ import os from 'node:os'
 import path from 'node:path'
 
 import { loggerService } from '@logger'
-import { isLinux, isPortable } from '@main/constant'
+import { isLinux, isPortable, isWin } from '@main/constant'
 import { audioExts, documentExts, imageExts, MB, textExts, videoExts } from '@shared/config/constant'
 import { FileMetadata, FileTypes } from '@types'
 import { app } from 'electron'
@@ -72,6 +72,10 @@ function getAppDataPathFromConfig() {
       executablePath = path.join(path.dirname(process.env.APPIMAGE), 'cherry-studio.appimage')
     }
 
+    if (isWin && isPortable) {
+      executablePath = path.join(process.env.PORTABLE_EXECUTABLE_DIR || '', 'cherry-studio-portable.exe')
+    }
+
     let appDataPath = null
     // 兼容旧版本
     if (config.appDataPath && typeof config.appDataPath === 'string') {
@@ -108,6 +112,11 @@ export function updateAppDataConfig(appDataPath: string) {
     executablePath = path.join(path.dirname(process.env.APPIMAGE), 'cherry-studio.appimage')
   }
 
+  // 如果是 Windows 可移植版本，则使用 PORTABLE_EXECUTABLE_FILE 环境变量
+  if (isWin && isPortable) {
+    executablePath = path.join(process.env.PORTABLE_EXECUTABLE_DIR || '', 'cherry-studio-portable.exe')
+  }
+
   if (!fs.existsSync(configPath)) {
     fs.writeFileSync(configPath, JSON.stringify({ appDataPath: [{ executablePath, dataPath: appDataPath }] }, null, 2))
     return